Pharmacokinetic and Metabolism Studies Using Microdialysis Sampling
نویسندگان
چکیده
منابع مشابه
Blood microdialysis in pharmacokinetic and drug metabolism studies.
Microdialysis is a sampling technique allowing measurement of endogenous and exogenous substances in the extracellular fluid surrounding the probe. In vivo microdialysis sampling offers several advantages over conventional methods of studying the pharmacokinetics and metabolism of xenobiotics, both in experimental animals and humans. In the first part of this review article various practical as...
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The objective of this study was to validate subcutaneous (sc) microdialysis sampling to study flurbiprofen pharmacokinetics and plasma protein binding in the awake freely moving rat. A linear microdialysis probe was manufactured using a Hemophane hollow fiber which was tested in vitro and in vivo for the recovery of flurbiprofen and naproxen used as retrodialysis marker. Flurbiprofen was admini...
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gaining acceptance in pharmacological studies (1,2). Numerous studies have demonstrated the capability of microdialysis sampling in characterizing the behavior of exogenous compounds in tissues such as blood (3-6), muscle (7,8), solid tumor (9), adipose (7,10), liver (1113), and dermis (14-17). Of all the commercially available probe designs, the BAS linear tissue probe (F1) is especially suita...
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Cerebral microdialysis is a sampling technique which offers much potential for understanding inflammatory pathophysiology following traumatic brain injury (TBI). At present, the recovery of cytokines via microdialysis in clinical studies is not straightforward primarily due to their size, steric properties and low concentrations. Heparin and heparin-coated microspheres have previously shown pro...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 1999
ISSN: 0022-3549
DOI: 10.1021/js9801485